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Mouse Anti-CAMK2G Recombinant Antibody (6A4A10) (CBMAB-0146CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
6A4A10
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Immunogen
Purified recombinant fragment of human CAMK2G (AA: 322-481) expressed in E. coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium/Calmodulin Dependent Protein Kinase II Gamma
Introduction
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.
Entrez Gene ID
818
UniProt ID
Q13555
Alternative Names
CAMK; CAMKG; CAMK-II
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290).
It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
Biological Process
Cell differentiation Source: UniProtKB-KW
Insulin secretion Source: UniProtKB
Interferon-gamma-mediated signaling pathway Source: Reactome
Nervous system development Source: UniProtKB-KW
Regulation of calcium ion transport Source: UniProtKB
Regulation of cellular response to heat Source: Reactome
Regulation of neuron projection development Source: UniProtKB
Regulation of skeletal muscle adaptation Source: UniProtKB
Cellular Location
Sarcoplasmic reticulum membrane
Involvement in disease
Intellectual developmental disorder, autosomal dominant 59 (MRD59): An autosomal dominant form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
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For research use only. Not intended for any clinical use.

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