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Rat Anti-CDNF Recombinant Antibody (CBFYC-1653) (CBMAB-C1714-FY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-1653
Antibody Isotype
IgG2a
Application
IHC

Basic Information

Immunogen
Recombinant mouse CDNF Leu27-Leu187.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 27-187

Target

Full Name
Cerebral Dopamine Neurotrophic Factor
Introduction
CDNF (Cerebral Dopamine Neurotrophic Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is MANF.
Entrez Gene ID
227526
UniProt ID
Q8CC36
Alternative Names
Armetl1; 9330140G23
Function
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Biological Process
Dopaminergic neuron differentiation Source: GO_Central
Neuron projection development Source: GO_Central
Cellular Location
Secreted
More Infomation

Lindholm, P., & Saarma, M. (2021). Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism. Molecular psychiatry, 1-12.

Eremin, D. V., Ilchibaeva, T. V., & Tsybko, A. S. (2021). Cerebral Dopamine Neurotrophic Factor (CDNF): Structure, Functions, and Therapeutic Potential. Biochemistry (Moscow), 86(7), 852-866.

Stepanova, P., Srinivasan, V., Lindholm, D., & Voutilainen, M. H. (2020). Cerebral dopamine neurotrophic factor (CDNF) protects against quinolinic acid-induced toxicity in in vitro and in vivo models of Huntington’s disease. Scientific reports, 10(1), 1-12.

Kidakova, A., Boroznjak, R., Reut, J., Öpik, A., Saarma, M., & Syritski, V. (2020). Molecularly imprinted polymer-based SAW sensor for label-free detection of cerebral dopamine neurotrophic factor protein. Sensors and Actuators B: Chemical, 308, 127708.

Lindahl, M., Chalazonitis, A., Palm, E., Pakarinen, E., Danilova, T., Pham, T. D., ... & Saarma, M. (2020). Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice. Neurobiology of disease, 134, 104696.

Chen, Y. C., Baronio, D., Semenova, S., Abdurakhmanova, S., & Panula, P. (2020). Cerebral Dopamine Neurotrophic Factor regulates multiple neuronal subtypes and behavior. Journal of Neuroscience, 40(32), 6146-6164.

Shirvani, H., Aslani, J., Mohammadi, Z. F., & Arabzadeh, E. (2019). Short-term effect of low-, moderate-, and high-intensity exercise training on cerebral dopamine neurotrophic factor (CDNF) and oxidative stress biomarkers in brain male Wistar rats. Comparative Clinical Pathology, 28(2), 369-376.

Nasrolahi, A., Mahmoudi, J., Karimipour, M., Akbarzadeh, A., Sadigh-Eteghad, S., Salehi, R., ... & Farhoudi, M. (2019). Effect of cerebral dopamine neurotrophic factor on endogenous neural progenitor cell migration in a rat model of Parkinson's disease. EXCLI journal, 18, 139.

Zhang, G. L., Wang, L. H., Liu, X. Y., Zhang, Y. X., Hu, M. Y., Liu, L., ... & Wang, X. J. (2018). Cerebral dopamine neurotrophic factor (CDNF) has neuroprotective effects against cerebral ischemia that may occur through the endoplasmic reticulum stress pathway. International journal of molecular sciences, 19(7), 1905.

Tang, T., Li, Y., Jiao, Q., Du, X., & Jiang, H. (2017). Cerebral dopamine neurotrophic factor: a potential therapeutic agent for Parkinson’s disease. Neuroscience bulletin, 33(5), 568-575.

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For research use only. Not intended for any clinical use.

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