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Human Anti-Cholera Toxin B Subunit Recombinant Antibody (CBMY-C0063) (CBMAB-V208-C0064-YY)


See all Cholera Toxin B Subunit antibodies
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Summary

Host Animal
Human
Specificity
Vibrio cholerae
Clone
CBMY-C0063
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Clostridium difficile Toxin B.
Host Species
Human
Specificity
Vibrio cholerae
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cholera Toxin B Subunit
Introduction
Cholera toxin (also known as choleragen and sometimes abbreviated to CTX, Ctx or CT) is protein complex secreted by the bacterium Vibrio cholerae. CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. The cholera toxin is an oligomeric complex made up of six protein subunits: a single copy of the A subunit (part A, enzymatic), and five copies of the B subunit (part B, receptor binding), denoted as AB5. Subunit B binds while subunit A activates the G protein which activates adenylate cyclase.
Function
The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
Biological Process
Killing of cells of other organism Source: TIGR
Pathogenesis Source: TIGR
Positive regulation of tyrosine phosphorylation of STAT protein Source: CACAO
Protein ADP-ribosylation Source: TIGR
Cellular Location
Secreted; Host cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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