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Mouse Anti-CHRNB3 Recombinant Antibody (3G6) (CBMAB-C6169-LY)

This product is antibody recognizes CHRNB3. The antibody 3G6 immunoassay techniques such as: ELISA, IF, WB.
Host Animal
Mouse
Application
ELISA, IF, WB
Antibody Isotype
IgG2b, κ
Specificity
Human
Cross Reactivity
Human
Clone
3G6
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]
Alternative Name
Cholinergic Receptor Nicotinic Beta 3 Subunit; Acetylcholine Receptor, Nicotinic, Beta 3 (Neuronal); Cholinergic Receptor, Nicotinic, Beta Polypeptide 3; Cholinergic Receptor, Nicotinic, Beta 3 (Neuronal); Cholinergic Receptor, Nicotinic Beta 3;
Entrez Gene ID
UniProt ID
Cat CBMAB-C6169-LY
Conjugates
Size
Price $
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