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Mouse Anti-CIR1 Recombinant Antibody (CBXC-0436) (CBMAB-C3181-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-0436
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-160 mapping at the N-terminus of CIR of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Corepressor Interacting With RBPJ, 1
Introduction
CIR1 (Corepressor Interacting With RBPJ, 1) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Notch signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity.
Entrez Gene ID
9541
UniProt ID
Q86X95
Alternative Names
Corepressor Interacting With RBPJ, 1; Recepin; CBF1-Interacting Corepressor; CIR; Corepressor Interacting With RBPJ 1; CBF1 Interacting Corepressor;
Function
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity).

Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Biological Process
In utero embryonic development Source: Ensembl
mRNA processing Source: UniProtKB-KW
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
RNA splicing Source: UniProtKB-KW
Cellular Location
Centrosome; Nucleus speckle. Colocalizes with NEK6 in the centrosome.
PTM
Phosphorylated by NEK6.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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