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Mouse Anti-CIR1 Recombinant Antibody (CBXC-0436) (CBMAB-C3181-CQ)

This product is a mouse antibody that recognizes CIR1. The antibody CBXC-0436 can be used for immunoassay techniques such as: ELISA, WB.
See all CIR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0436
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Corepressor Interacting With RBPJ, 1
Introduction
CIR1 (Corepressor Interacting With RBPJ, 1) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Notch signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity.
Entrez Gene ID
9541
UniProt ID
Q86X95
Alternative Names
Corepressor Interacting With RBPJ, 1; Recepin; CBF1-Interacting Corepressor; CIR; Corepressor Interacting With RBPJ 1; CBF1 Interacting Corepressor;
Function
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity).

Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Biological Process
In utero embryonic development Source: Ensembl
mRNA processing Source: UniProtKB-KW
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
RNA splicing Source: UniProtKB-KW
Cellular Location
Centrosome; Nucleus speckle. Colocalizes with NEK6 in the centrosome.
PTM
Phosphorylated by NEK6.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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