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Mouse Anti-CRELD1 Recombinant Antibody (CBFYC-2204) (CBMAB-C2274-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2204
Antibody Isotype
IgG2b
Application
Neutralization

Basic Information

Immunogen
Recombinant human CRELD-1 Gln30-Glu362.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cysteine Rich With EGF Like Domains 1
Introduction
CRELD1 (Cysteine Rich With EGF Like Domains 1) is a Protein Coding gene. Diseases associated with CRELD1 include Atrioventricular Septal Defect 2 and Partial Atrioventricular Canal. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CRELD2.
Entrez Gene ID
78987
UniProt ID
Q96HD1
Alternative Names
Cysteine Rich With EGF Like Domains 1; CIRRIN; Cysteine-Rich With EGF-Like Domain Protein 1; Cysteine-Rich With EGF-Like Domains 1; Cysteine Rich With EGF-Like Domains 1; Atrioventricular Septal Defect 2; AVSD2
Function
Protein disulfide isomerase (By similarity).

Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity).
Biological Process
Cardiac septum development Source: BHF-UCL
Endocardial cushion development Source: BHF-UCL
Cellular Location
Membrane
Involvement in disease
Atrioventricular septal defect 2 (AVSD2):
A congenital heart malformation characterized by a common atrioventricular junction coexisting with deficient atrioventricular septation. The complete form involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum; the valve itself is also shared. A less severe form, known as ostium primum atrial septal defect, is characterized by separate atrioventricular valvar orifices despite a common junction.
Topology
Extracellular: 30-362
Helical: 363-383
Cytoplasmic: 384
Helical: 385-405
Extracellular: 406-420
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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