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Mouse Anti-CRTAP Recombinant Antibody (CBYY-C2881) (V2LY-1206-LY1246)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Dog, Pig
Clone
CBYY-C2881
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 355-387 near the C-terminus of human CRTAP.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Dog, Pig
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cartilage associated protein
Entrez Gene ID
Human10491
Rat102555086
UniProt ID
HumanO75718
RatM0R3U4
Function
Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
Biological Process
Chaperone-mediated protein folding Source: UniProtKB
Collagen fibril organization Source: GO_Central
Negative regulation of post-translational protein modification Source: UniProtKB
Peptidyl-proline hydroxylation to 3-hydroxy-L-proline Source: GO_Central
Protein stabilization Source: UniProtKB
Spermatogenesis Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Osteogenesis imperfecta 7 (OI7):
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI7 is an autosomal recessive, severe form. Multiple fractures are present at birth and patients have short stature, short humeri and femora, coxa vara, and white sclera. Dentinogenesis imperfecta is absent. Death can occur in the perinatal period due to secondary respiratory insufficiency.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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