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Mouse Anti-DDX3Y Recombinant Antibody (CBYCD-218) (CBMAB-D0566-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYCD-218
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Immunogen
DDX3Y (NP_004651, 1 a.a. ~ 80 a.a) partial recombinant protein with GST tag.
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Concentration
0.4 mg/mL
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-81

Target

Full Name
DEAD-Box Helicase 3, Y-Linked
Introduction
DDX3Y is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome.
Entrez Gene ID
8653
UniProt ID
O15523
Alternative Names
DEAD-Box Helicase 3, Y-Linked; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide, Y Chromosome; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, Y-Linked; DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, Y-Linked; DEAD Box Protein 3, Y-Chromosomal; DBY; ATP-Dependent RNA Helicase DDX3Y; EC 3.6.4.13; EC 3.6.1;
Function
Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity).
Biological Process
Cell differentiation Source: GO_Central
Gamete generation Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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