Mouse Anti-DLG1 Recombinant Antibody (4D6) (CBMAB-0484-CN)

Mouse

Human

4D6

IgG

ELISA, MA

Recombinant protein of DLG1 (aa. 224-312)

Human

IgG

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

>95%, as determined by SDS-PAGE analysis

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

DLG1

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.

Discs, Large Homolog 1 (Drosophila); Synapse-Associated Protein 97; Presynaptic Protein SAP97; SAP-97; SAP97; Hdlg; Discs, Large (Drosophila) Homolog 1; Discs Large Homolog 1; DJ1061C18.1.1; DLGH1

Essential multidomain scaffolding protein required for normal development (By similarity).

Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497).

Actin filament organization Source: UniProtKB
Activation of protein kinase activity Source: Ensembl
Amyloid precursor protein metabolic process Source: Ensembl
Astral microtubule organization Source: UniProtKB
Bicellular tight junction assembly Source: BHF-UCL
Branching involved in ureteric bud morphogenesis Source: Ensembl
Cell-cell adhesion Source: UniProtKB
Cellular protein-containing complex localization Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Cortical actin cytoskeleton organization Source: UniProtKB
Cortical microtubule organization Source: UniProtKB
Embryonic skeletal system morphogenesis Source: Ensembl
Endothelial cell proliferation Source: UniProtKB
Establishment of centrosome localization Source: UniProtKB
Establishment or maintenance of cell polarity Source: UniProtKB
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Hard palate development Source: Ensembl
Immunological synapse formation Source: Ensembl
Lens development in camera-type eye Source: Ensembl
Membrane raft organization Source: Ensembl
Negative regulation of epithelial cell proliferation Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Negative regulation of p38MAPK cascade Source: UniProtKB
Negative regulation of protein kinase B signaling Source: Ensembl
Negative regulation of T cell proliferation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Neurotransmitter receptor localization to postsynaptic specialization membrane Source: GO_Central
Peristalsis Source: Ensembl
Positive regulation of actin filament polymerization Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of potassium ion transport Source: BHF-UCL
Positive regulation of protein localization to plasma membrane Source: BHF-UCL
Protein localization to plasma membrane Source: BHF-UCL
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Regulation of cell shape Source: UniProtKB
Regulation of membrane potential Source: BHF-UCL
Regulation of myelination Source: Ensembl
Regulation of potassium ion export across plasma membrane Source: BHF-UCL
Regulation of potassium ion import Source: BHF-UCL
Regulation of protein localization to synapse Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
Regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential Repolarization Source: BHF-UCL
Reproductive structure development Source: Ensembl
Smooth muscle tissue development Source: Ensembl
T cell activation Source: Ensembl

Basolateral cell membrane; Sarcolemma; Apical cell membrane; Cytoplasm; Endoplasmic reticulum membrane; Membrane; Postsynaptic density; Synapse; Cell junction. Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells (PubMed:12807908). May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity).

Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity).