Sign in or Register   Sign in or Register
  |  

Mouse Anti-E2F6 Recombinant Antibody (CBFYE-0378) (CBMAB-E0683-FY)

This product is mouse antibody that recognizes E2F6. The antibody CBFYE-0378 can be used for immunoassay techniques such as: ELISA, WB, IP, GS.
See all E2F6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBFYE-0378
Antibody Isotype
IgG
Application
ELISA, WB, IP, GS

Basic Information

Immunogen
Antibody was raised against 6x His-tagged full length human E2F6, purified from bacteria
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
E2F Transcription Factor 6
Introduction
This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription.
Entrez Gene ID
Human1876
Mouse50496
UniProt ID
HumanO75461
MouseO54917
Alternative Names
E2F-6
Research Area
Inhibitor of E2F-dependent transcription (PubMed:9689056, PubMed:9704927, PubMed:9501179).

Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179).

Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179).

E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9704927, PubMed:9501179).

Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9689056, PubMed:9501179).

Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity).

May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179).
Biological Process
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Ensembl
Cellular Location
Nucleus
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-E2F6 Recombinant Antibody (CBFYE-0378)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare