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Rabbit Anti-ELL2 Recombinant Antibody (EG1090) (CBMAB-EN1286-LY)

The product is antibody recognizes ELL2. The antibody EG1090 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:20000.
See all ELL2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1090
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human ELL2.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Elongation Factor For RNA Polymerase II 2
Introduction
ELL2 (Elongation Factor For RNA Polymerase II 2) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA polymerase II transcribes snRNA genes. An important paralog of this gene is ELL.
Entrez Gene ID
Human22936
Mouse192657
UniProt ID
HumanO00472
MouseQ3UKU1
Alternative Names
Elongation Factor For RNA Polymerase II 2; Metastatic Renal Cell Carcinoma-Associated Transcript 1; Elongation Factor, RNA Polymerase II, 2; ELL-Related RNA Polymerase II, Elongation Factor; Elongation Factor RNA For Polymerase II 2; RNA Polymerase II Elongation Factor ELL2; MRCCAT1;
Research Area
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).

Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.
Biological Process
snRNA transcription by RNA polymerase II Source: UniProtKB
Transcription elongation from RNA polymerase II promoter Source: ProtInc
Cellular Location
Nucleus
PTM
Ubiquitinated by SIAH1, leading to its degradation by the proteaseome. Interaction with AFF4 stabilizeS ELL2 and prevent ELL2 ubiquitination.

Shrestha, S., Aryal, S., Siddam, A., Hernandez, F., & Lachke, S. A. (2022). Deficiency of the transcription elongation factor Ell2, a downstream target of the cataract-linked RNA-binding protein Celf1, causes eye defects. Investigative Ophthalmology & Visual Science, 63(7), 653-F0008.

Kohrt, S., Strobel, S., Mann, M. C., Sticht, H., Fleckenstein, B., & Thoma-Kress, A. K. (2021). Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation. International Journal of Molecular Sciences, 22(24), 13597.

Shrestha, S. K., Aryal, S., Siddam, A. D., Hernandez, F., & Lachke, S. A. (2020). Investigation of the transcription elongation factor Ell2 in lens development. Investigative Ophthalmology & Visual Science, 61(7), 2861-2861.

Wu, J., Xue, Y., Gao, X., & Zhou, Q. (2020). Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2. Nucleic acids research, 48(13), 7321-7332.

Zhong, M., Pascal, L. E., Cheng, E., Masoodi, K. Z., Chen, W., Green, A., ... & Wang, Z. (2018). Concurrent EAF2 and ELL2 loss phenocopies individual EAF2 or ELL2 loss in prostate cancer cells and murine prostate. American journal of clinical and experimental urology, 6(6), 234.

Chen, F. X., Smith, E. R., & Shilatifard, A. (2018). Born to run: control of transcription elongation by RNA polymerase II. Nature reviews Molecular cell biology, 19(7), 464-478.

Zhong, M., Pascal, L., Song, Q., Chen, W., & Wang, Z. (2018, November). ELL2 and EAF2 co-regulation of AKT in prostate cancer cells. In Endocrine Abstracts (Vol. 59). Bioscientifica.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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