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Rabbit Anti-ELOVL1 Recombinant Antibody (EG1094) (CBMAB-EN1290-LY)

The product is antibody recognizes ELOVL1. The antibody EG1094 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all ELOVL1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1094
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human ELOVL1.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ELOVL Fatty Acid Elongase 1
Introduction
ELOVL1 (ELOVL Fatty Acid Elongase 1) is a Protein Coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and alpha-linolenic acid (ALA) metabolism. Gene Ontology (GO) annotations related to this gene include fatty acid elongase activity. An important paralog of this gene is ELOVL7.
Entrez Gene ID
Human64834
Mouse54325
UniProt ID
HumanQ9BW60
MouseQ9JLJ5
Alternative Names
ELOVL Fatty Acid Elongase 1; Elongation Of Very Long Chain Fatty Acids (FEN1/Elo2, SUR4/Elo3, Yeast)-Like 1; Very Long Chain 3-Ketoacyl-CoA Synthase 1; Very Long Chain 3-Oxoacyl-CoA Synthase 1; 3-Keto Acyl-CoA Synthase ELOVL1; ELOVL FA Elongase 1;
Research Area
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246).

This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905).

Indirectly inhibits RPE65 via production of VLCFAs.
Biological Process
Alpha-linolenic acid metabolic process Source: Reactome
Ceramide biosynthetic process Source: Ensembl
Establishment of skin barrier Source: Ensembl
Fatty acid elongation, monounsaturated fatty acid Source: UniProtKB
Fatty acid elongation, polyunsaturated fatty acid Source: GO_Central
Fatty acid elongation, saturated fatty acid Source: UniProtKB
Linoleic acid metabolic process Source: Reactome
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Sphingolipid biosynthetic process Source: UniProtKB
Unsaturated fatty acid biosynthetic process Source: UniProtKB-UniRule
Very long-chain fatty acid biosynthetic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facies (IKSHD):
An autosomal dominant disease characterized by ichthyosis due to epidermal hyperproliferation and increased keratinisation, hypomyelination of the central white matter, spastic paraplegia, central nystagmus, optic atrophy, reduction of peripheral vision and visual acuity, and dysmorphic facial features.

Trauner, D., & Arp, C. J. (2022). Central Nervous System-Penetrant Inhibitors of ELOVL1. Synfacts, 18(03), 0328.

Boyd, M. J., Collier, P. N., Clark, M. P., Deng, H., Kesavan, S., Ronkin, S. M., ... & Magavi, S. S. (2021). Discovery of novel, orally bioavailable pyrimidine ether-based inhibitors of Elovl1. Journal of Medicinal Chemistry, 64(24), 17777-17794.

Come, J. H., Senter, T. J., Clark, M. P., Court, J. J., Gale-Day, Z., Gu, W., ... & Magavi, S. S. (2021). Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1. Journal of Medicinal Chemistry, 64(24), 17753-17776.

Jin, M., Gottschalk, L. N., & Li, S. (2020). The Putative Iron-Binding Histidines of ELOVL1 are Essential for Inhibiting 11-cis-Retinol Synthesis Catalyzed by RPE65 Isomerase. Investigative Ophthalmology & Visual Science, 61(7), 4976-4976.

Bhandari, S., & Choe, S. K. (2019). The Role of a Fatty Acid Chain Elongase, Elovl1, in Zebrafish and Its Implications for Kidney Disease in Humans. In The Molecular Nutrition of Fats (pp. 249-260). Academic Press.

Mueller, N., Sassa, T., Morales-Gonzalez, S., Schneider, J., Salchow, D. J., Seelow, D., ... & Schuelke, M. (2019). De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy. Journal of medical genetics, 56(3), 164-175.

Isokawa, M., Sassa, T., Hattori, S., Miyakawa, T., & Kihara, A. (2019). Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1. FASEB BioAdvances, 1(12), 747-759.

Kutkowska-Kaźmierczak, A., Rydzanicz, M., Chlebowski, A., Kłosowska-Kosicka, K., Mika, A., Gruchota, J., ... & Płoski, R. (2018). Dominant ELOVL1 mutation causes neurological disorder with ichthyotic keratoderma, spasticity, hypomyelination and dysmorphic features. Journal of medical genetics, 55(6), 408-414.

Sassa, T., Tadaki, M., Kiyonari, H., & Kihara, A. (2018). Very long‐chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice. The FASEB Journal, 32(6), 2966-2978.

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For research use only. Not intended for any clinical use.

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