Rabbit Anti-ELP2 Recombinant Antibody (EG1100) (CBMAB-EN1296-LY)

The product is antibody recognizes ELP2. The antibody EG1100 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all ELP2 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG1100

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human ELP2.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Elongator Acetyltransferase Complex Subunit 2

Introduction

The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]

Entrez Gene ID

55250

UniProt ID

Q6IA86

Alternative Names

Elongator Acetyltransferase Complex Subunit 2; Signal Transducer And Activator Of Transcription 3 Interacting Protein 1; STAT3-Interacting Protein 1; STATIP1; SHINC-2; Elongation Protein 2 Homolog (S. Cerevisiae); Elongation Protein 2 Homolog;

Research Area

Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576).

The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244).

Biological Process

Regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
Regulation of transcription by RNA polymerase II Source: HGNC-UCL
Transcription elongation from RNA polymerase II promoter Source: BHF-UCL
tRNA wobble uridine modification Source: InterPro

Cellular Location

Nucleus; Cytoplasm

Involvement in disease

Mental retardation, autosomal recessive 58 (MRT58):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT58 transmission pattern is consistent with autosomal recessive inheritance.

References

Kojic, M., Gawda, T., Gaik, M., Begg, A., Salerno-Kochan, A., Kurniawan, N. D., ... & Wainwright, B. J. (2021). Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nature communications, 12(1), 1-18.

Zhao, Y. C., Tang, D., Yang, S., Liu, H., Luo, S., Stinchcombe, T. E., ... & Wei, Q. (2020). Novel Variants of ELP2 and PIAS1 in the Interferon Gamma Signaling Pathway Are Associated with Non–Small Cell Lung Cancer Survival. Cancer Epidemiology, Biomarkers & Prevention, 29(8), 1679-1688.

Xu, C. P., Sun, H. T., Yang, Y. J., Cui, Z., Wang, J., Yu, B., ... & Qi, Y. (2019). ELP2 negatively regulates osteoblastic differentiation impaired by tumor necrosis factor α in MC3T3–E1 cells through STAT3 activation. Journal of Cellular Physiology, 234(10), 18075-18085.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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