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Mouse Anti-EMG1 Recombinant Antibody (CBFYE-0822) (CBMAB-E1274-FY)

This product is mouse antibody that recognizes EMG1. The antibody CBFYE-0822 can be used for immunoassay techniques such as: WB, FC, IF.
See all EMG1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Dog, Human, Monkey
Clone
CBFYE-0822
Antibody Isotype
IgG2b
Application
WB, FC, IF

Basic Information

Immunogen
Full length human recombinant protein of human EMG1 produced in HEK293T cell
Specificity
Rat, Dog, Human, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Emg1, N1-Specific Pseudouridine Methyltransferase
Introduction
This gene encodes an essential, conserved eukaryotic protein that methylates pseudouridine in 18S rRNA. The related protein in yeast is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human10436
Dog477708
Rat312706
Monkey722122
UniProt ID
HumanQ92979
DogE2RKH8
RatD3ZDS4
MonkeyG7PJP2
Alternative Names
EMG1, N1-Specific Pseudouridine Methyltransferase; 18S RRNA (Pseudouridine(1248)-N1)-Methyltransferase; 18S RRNA Psi1248 Methyltransferase; Ribosome Biogenesis Protein NEP1; C2F; 18S RRNA (Pseudouridine-N1-)-Methyltransferase NEP1; Ribosomal RNA Small Subunit Methyltransferase NEP1; EMG1 Nucleolar Protein Homolog (S. Cerevisiae); EMG1 Nucleolar Protein Homolog
Research Area
S-adenosyl-L-methionine-dependent pseudouridine N1-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967).

Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity).
Biological Process
Blastocyst development Source: Ensembl
Nucleologenesis Source: Ensembl
Ribosomal small subunit biogenesis Source: UniProtKB
rRNA base methylation Source: GO_Central
rRNA processing Source: UniProtKB
Cellular Location
Nucleolus
Involvement in disease
Bowen-Conradi syndrome (BWCNS):
A combination of malformations characterized in newborns by low birth weight, microcephaly, mild joint restriction, a prominent nose, micrognathia, fifth finger clinodactyly, and 'rocker-bottom' feet. The syndrome is transmitted as an autosomal recessive trait. The prognosis is poor, with all infants dying within the first few months of life.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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