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Mouse Anti-EMX2 (AA 103-200) Recombinant Antibody (CBFYE-0838) (CBMAB-E1293-FY)

This product is mouse antibody that recognizes EMX2. The antibody CBFYE-0838 can be used for immunoassay techniques such as: ELISA, ICC, IF.
See all EMX2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0838
Antibody Isotype
IgG2b, κ
Application
ELISA, ICC, IF

Basic Information

Immunogen
EMX2 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 103-200

Target

Full Name
Empty Spiracles Homeobox 2
Introduction
This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Entrez Gene ID
2018
UniProt ID
Q04743
Alternative Names
Empty Spiracles Homeobox 2; Empty Spiracles Homolog 2 (Drosophila); Empty Spiracles-Like Protein 2; Empty Spiracles Homolog 2
Research Area
Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
Biological Process
Anterior/posterior pattern specification Source: Ensembl
Brain development Source: GO_Central
Cell proliferation in forebrain Source: Ensembl
Central nervous system development Source: GO_Central
Cerebral cortex regionalization Source: Ensembl
Dentate gyrus development Source: Ensembl
Forebrain cell migration Source: Ensembl
Neuron differentiation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to drug Source: Ensembl
Ureter morphogenesis Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Schizencephaly (SCHZC):
Extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro-spinal fluid.

Li, H., Liao, S., Luo, G., Li, H., Wang, S., Li, Z., & Luo, X. (2022). An Association between EMX2 Variations and Mayer-Rokitansky-Küster-Hauser Syndrome: A Case-Control Study of Chinese Women. Journal of Healthcare Engineering, 2022.

Nguyen, K., & Wingert, R. (2022). emx2is Required for Nephron Segment Development in the Zebrafish Pronephros. The FASEB Journal, 36.

Jimenez-García, M. P., Lucena-Cacace, A., Otero-Albiol, D., & Carnero, A. (2021). Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis. Journal of Experimental & Clinical Cancer Research, 40(1), 1-18.

Jimenez-García, M. P., Lucena-Cacace, A., Otero-Albiol, D., & Carnero, A. (2021). Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2. Cell death & disease, 12(6), 1-17.

Luo, X., Yang, R., Bai, Y., Li, L., Lin, N., Sun, L., ... & Wu, Z. (2021). Binding of microRNA-135a (miR-135a) to homeobox protein A10 (HOXA10) mRNA in a high-progesterone environment modulates the embryonic implantation factors beta3-integrin (ITGβ3) and empty spiracles homeobox-2 (EMX2). Annals of Translational Medicine, 9(8).

Wang, L., Jin, J., Zhou, Y., Tian, Z., He, B., Huang, Y., & Ding, F. (2019). EMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. Oncology Reports, 42(5), 2169-2178.

Wei, X. F., Chen, Q. L., Fu, Y., & Zhang, Q. K. (2019). Wnt and BMP signaling pathways co‐operatively induce the differentiation of multiple myeloma mesenchymal stem cells into osteoblasts by upregulating EMX2. Journal of Cellular Biochemistry, 120(4), 6515-6527.

Groves, J. A., Gillman, C., DeLay, C. N., & Kroll, T. T. (2019). Identification of Novel Binding Partners for Transcription Factor Emx2. The Protein Journal, 38(1), 2-11.

Monnier, A., Boniface, R., Bouvet, R., Etcheverry, A., Aubry, M., Avril, T., ... & Mosser, J. (2018). The expression of EMX2 lead to cell cycle arrest in glioblastoma cell line. BMC cancer, 18(1), 1-11.

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For research use only. Not intended for any clinical use.

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