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Rabbit Anti-ENAH Recombinant Antibody (CBFYM-1082) (CBMAB-M1237-FY)

This product is rabbit antibody that recognizes ENAH. The antibody CBFYM-1082 can be used for immunoassay techniques such as: WB, IP.
See all ENAH antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBFYM-1082
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ENAH, Actin Regulator
Introduction
This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3.
Entrez Gene ID
Human55740
Mouse13800
Rat360891
UniProt ID
HumanQ8N8S7
MouseQ03173
RatQ5XHX3
Alternative Names
ENAH, Actin Regulator; MENA; Mammalian Enabled Variant 11a; Mammalian Enabled Variant Pan; Enabled Homolog (Drosophila); Protein Enabled Homolog
Research Area
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).
Biological Process
Actin polymerization-dependent cell motility Source: GO_Central
Actin polymerization or depolymerization Source: GO_Central
Axon guidance Source: GO_Central
Cellular Location
Cytoskeleton; Cytoplasm; Lamellipodium; Filopodium; Synapse; Focal adhesion. Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity).
PTM
NTN1-induced PKA phosphorylation on Ser-265 directly parallels the formation of filopodial protrusions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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