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Mouse Anti-ENTPD4 (AA 371-469) Recombinant Antibody (CBFYE-0222) (CBMAB-E0472-FY)

This product is mouse antibody that recognizes ENTPD4. The antibody CBFYE-0222 can be used for immunoassay techniques such as: ELISA, WB.
See all ENTPD4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0222
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant from ENTPD4 with GST tag MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 371-469

Target

Full Name
ectonucleoside triphosphate diphosphohydrolase 4
Introduction
This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes.
Entrez Gene ID
9583
UniProt ID
Q9Y227
Alternative Names
LAP70; LALP70; LYSAL1; UDPase; NTPDase-4
Research Area
Isoform 1:
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635).

Preferentially activated by Ca2+ over Mg2+ (PubMed:10858452).

Isoform 2:
Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca2+ or Mg2+ equally.
Biological Process
CTP metabolic process Source: UniProtKB
GDP catabolic process Source: UniProtKB
Nucleobase-containing small molecule catabolic process Source: UniProtKB
Nucleoside diphosphate catabolic process Source: GO_Central
UDP catabolic process Source: UniProtKB
Cellular Location
Isoform 1: Lysosome membrane; Autophagosome membrane
Isoform 2: Golgi apparatus membrane
Topology
Cytoplasmic: 1-33
Helical: 34-54
Lumenal: 55-559
Helical: 560-580
Cytoplasmic: 581-616
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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