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Mouse Anti-EPB42 Recombinant Antibody (2G12) (CBMAB-A2635-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2G12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
EPB42 (NP_000110.1, 623 a.a. ~ 721 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
erythrocyte membrane protein band 4.2
Introduction
Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
2038
UniProt ID
P16452
Alternative Names
MGC116735; MGC116737; PA
Research Area
Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.
Biological Process
Cell morphogenesis Source: Ensembl
Erythrocyte maturation Source: UniProtKB-KW
Hemoglobin metabolic process Source: Ensembl
Iron ion homeostasis Source: Ensembl
Peptide cross-linking Source: GO_Central
Regulation of cell shape Source: UniProtKB-KW
Spleen development Source: Ensembl
Cellular Location
Cytoskeleton; Cell membrane. Cytoplasmic surface of erythrocyte membranes.
Involvement in disease
Spherocytosis 5 (SPH5):
Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.
PTM
Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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