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Mouse Anti-ERI1 Recombinant Antibody (CBFYE-1194) (CBMAB-E1764-FY)

This product is mouse antibody that recognizes ERI1. The antibody CBFYE-1194 can be used for immunoassay techniques such as: WB, IHC.
See all ERI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Monkey
Clone
CBFYE-1194
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human ERI1 produced in HEK293T cell
Specificity
Human, Rat, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1%BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
1.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Exoribonuclease 1
Introduction
ERI1 (Exoribonuclease 1) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribosome binding. An important paralog of this gene is ERI3.
Entrez Gene ID
Human90459
Monkey699381
Rat361159
UniProt ID
HumanQ8IV48
MonkeyA0A2K5V361
RatQ5FVR4
Alternative Names
Exoribonuclease 1; Histone MRNA 3-End-Specific Exoribonuclease; Three Prime Histone MRNA Exonuclease 1; Histone MRNA 3-Exonuclease 1; 3-5 Exonuclease ERI1; THEX1; HEXO; Enhanced RNAi Three Prime MRNA Exonuclease Homolog 1 (C.Elegans); Enhanced RNAi Three Prime MRNA Exonuclease Homolog 1; Histone MRNA 3 End-Specific Exonuclease
Research Area
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Biological Process
Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Gene silencing by RNA Source: UniProtKB-KW
rRNA 3'-end processing Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus; Nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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