Rabbit Anti-EPS8L3 Recombinant Antibody (EG1146) (CBMAB-EN1366-LY)

The product is antibody recognizes ES8L3. The antibody EG1146 immunoassay techniques such as: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:10000.
See all EPS8L3 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG1146

Antibody Isotype

IgG

Application

IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human ES8L3.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Eps8 Like 3

Entrez Gene ID

79574

UniProt ID

Q8TE67

Biological Process

Positive regulation of ruffle assembly Source: GO_Central
Regulation of catalytic activity Source: GOC
Regulation of hair cycle Source: UniProtKB
Regulation of Rho protein signal transduction Source: GO_Central
Rho protein signal transduction Source: GO_Central

Cellular Location

Cytoplasm

Involvement in disease

Hypotrichosis 5 (HYPT5):
A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT5 is an autosomal dominant form characterized by little or no scalp hair at birth, wiry and irregular scalp hair in childhood, and sparse or no forehead and parietal hair at puberty. Eyebrows and eyelashes are thin, and pubic and axillary hair fails to develop. Scarring alopecia is modest, and vertex hair is normal.

References

You, L., Xiao, L., & Jin, S. (2022). EPS8L3 suppresses apoptosis and autophagy of gastric cancer through PI3K/AKT/mTOR signaling. Molecular & Cellular Toxicology, 1-9.

Xuan, Z., Zhao, L., Li, Z., Song, W., Chen, J., Chen, J., ... & Song, P. (2020). EPS8L3 promotes hepatocellular carcinoma proliferation and metastasis by modulating EGFR dimerization and internalization. American journal of cancer research, 10(1), 60.

Chen, B., Pan, Y., Xu, X., Wu, F., Zheng, X., Chen, S. Y., ... & Li, Y. X. (2020). Inhibition of EPS8L3 suppresses liver cancer progression and enhances efficacy of sorafenib treatment. Biomedicine & Pharmacotherapy, 128, 110284.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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