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Mouse Anti-ETV1 (AA 148-257) Recombinant Antibody (CBFYE-1350) (CBMAB-E1964-FY)

This product is mouse antibody that recognizes ETV1. The antibody CBFYE-1350 can be used for immunoassay techniques such as: ELISA, WB.
See all ETV1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1350
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa148-257 from ETV1 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 148-257

Target

Full Name
ETS Variant 1
Introduction
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Entrez Gene ID
2115
UniProt ID
P50549
Alternative Names
ETS Variant 1; Ets-Related Protein 81; Ets Variant Gene 1; ER81; ETS Translocation Variant 1
Research Area
Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
Biological Process
Axon guidance Source: Ensembl
Cell differentiation Source: GO_Central
Mechanosensory behavior Source: Ensembl
Muscle organ development Source: Ensembl
Peripheral nervous system neuron development Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Ewing sarcoma (ES):
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
PTM
Sumoylated.
Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.

Askar, P., Xu, J., Hu, J., Shangguan, J., Sun, H., Zhou, S., ... & Gu, Y. (2022). The Etv1/Er81 transcription factor coordinates myelination-related genes to regulate Schwann cell differentiation and myelination. Annals of translational medicine, 10(16), 875-875.

Oh, S., Shin, S., & Janknecht, R. (2021). Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer. International Journal of Clinical and Experimental Pathology, 14(7), 795.

Zhou, Y., Bai, H., Xia, J., Xu, W. Y., Cheng, L., & Xiong, L. (2021). Novel ETV1 mutation in small cell lung cancer transformation resistant to EGFR tyrosine kinase inhibitors. Annals of Translational Medicine, 9(14).

Oh, S., Song, H., Freeman, W. M., Shin, S., & Janknecht, R. (2020). Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer. International journal of oncology, 57(6), 1319-1332.

Matjašič, A., Zupan, A., Boštjančič, E., Pižem, J., Popović, M., & Kolenc, D. (2020). A novel PTPRZ1‐ETV1 fusion in gliomas. Brain Pathology, 30(2), 226-234.

Khatiwada, P., Kannan, A., Malla, M., Dreier, M., & Shemshedini, L. (2020). Androgen up-regulation of Twist1 gene expression is mediated by ETV1. PeerJ, 8, e8921.

Oh, S., Shin, S., Song, H., Grande, J. P., & Janknecht, R. (2019). Relationship between ETS transcription factor ETV1 and TGF-β-regulated SMAD proteins in prostate cancer. Scientific reports, 9(1), 1-12.

Eid, W., & Abdel‐Rehim, W. (2019). Genome‐wide analysis of ETV1 targets: Insights into the role of ETV1 in tumor progression. Journal of Cellular Biochemistry, 120(6), 8983-8991.

Rommel, C., Roesner, S., Lother, A., Barg, M., Schwaderer, M., Gilsbach, R., ... & Hein, L. (2018). The transcription factor ETV1 induces atrial remodeling and arrhythmia. Circulation Research, 123(5), 550-563.

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For research use only. Not intended for any clinical use.

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