Mouse Anti-EXOC6 Recombinant Antibody (CBFYE-1386) (CBMAB-E2004-FY)

Name: Mouse Anti-EXOC6 Recombinant Antibody (CBFYE-1386)
SKU: CBMAB-E2004-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat

Clone

CBFYE-1386

Antibody Isotype

IgG

Application

WB, ELISA, IF

Basic Information

Specificity

Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Exocyst Complex Component 6

Introduction

The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2.

Entrez Gene ID

Mouse	107371
Rat	50556

UniProt ID

Mouse	Q8R313
Rat	O54923

Alternative Names

hbd; Sec15; msec15; Sec15l1; AW413330; C430002C19; 4833405E05Rik

Research Area

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).

Biological Process

Exocytosis Source: GO_Central
Golgi to plasma membrane transport Source: GO_Central
Intracellular protein transport Source: InterPro
Vesicle tethering involved in exocytosis Source: InterPro

Cellular Location

Cytoplasm; Perinuclear region; Growth cone; Midbody ring. Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214).

More Infomation

References

Sulaiman, N., Yaseen Hachim, M., Khalique, A., Mohammed, A. K., Al Heialy, S., & Taneera, J. (2022). EXOC6 (Exocyst Complex Component 6) Is Associated with the Risk of Type 2 Diabetes and Pancreatic β-Cell Dysfunction. Biology, 11(3), 388.

Hachim, M. Y., Hachim, I. Y., Al Heialy, S., & Taneera, J. (2020). Cellular exocytosis gene (EXOC6/6B): a potential molecular link for the susceptibility and mortality of COVID-19 in diabetic patients. bioRxiv.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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