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Mouse Anti-EXOC8 Recombinant Antibody (CBFYE-1382) (CBMAB-E2000-FY)

This product is mouse antibody that recognizes EXOC8. The antibody CBFYE-1382 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all EXOC8 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYE-1382
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Exocyst Complex Component 8
Introduction
This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane.
Entrez Gene ID
Human149371
Mouse102058
Rat245709
UniProt ID
HumanQ8IYI6
MouseQ6PGF7
RatO54924
Alternative Names
EXO84; SEC84; Exo84p
Research Area
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Biological Process
Cellular protein localization Source: Ensembl
Endosome organization Source: UniProtKB
Exocytosis Source: MGI
Extracellular matrix disassembly Source: UniProtKB
Golgi to plasma membrane transport Source: GO_Central
Protein localization Source: GO_Central
Protein transport Source: UniProtKB-KW
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Cellular Location
Cytoplasm; Perinuclear region; Growth cone; Cell projection. Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Localizes at the leading edge of migrating cells (By similarity).
Involvement in disease
Neurodevelopmental disorder with microcephaly, seizures, and brain atrophy (NEDMISB): An autosomal recessive neurodevelopmental disorder characterized by severe global developmental delay, developmental regression with loss of milestones, severe microcephaly, and brain abnormalities, primarily cerebral atrophy and hypoplasia of the corpus callosum. Affected individuals develop seizures in the first year of life. Death in childhood may occur.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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