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Mouse Anti-EXOSC7 Recombinant Antibody (2335C2a) (CBMAB-E2029-FY)

This product is mouse antibody that recognizes EXOSC7. The antibody 2335C2a can be used for immunoassay techniques such as: DB, WB, FC.
See all EXOSC7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2335C2a
Antibody Isotype
IgG1
Application
DB, WB, FC

Basic Information

Immunogen
EXOSC7 antibody was raised in mouse using recombinant Human Exosome Component 7
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
exosome component 7
Introduction
EXOSC7 (Exosome Component 7) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and exoribonuclease activity. An important paralog of this gene is EXOSC9.
Entrez Gene ID
Human23016
Mouse66446
Rat316098
UniProt ID
HumanQ15024
MouseQ9D0M0
RatG3V6K3
Alternative Names
Exosome Component 7; Ribosomal RNA-Processing Protein 42; RRP42; P8; Exosome Complex Exonuclease RRP42; Exosome Complex Component RRP42
Research Area
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Biological Process
Exonucleolytic catabolism of deadenylated mRNA Source: GO_Central
Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Nuclear mRNA surveillance Source: GO_Central
Nuclear polyadenylation-dependent mRNA catabolic process Source: GO_Central
Nuclear polyadenylation-dependent rRNA catabolic process Source: GO_Central
Nuclear polyadenylation-dependent tRNA catabolic process Source: GO_Central
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' Source: GO_Central
RNA catabolic process Source: UniProtKB
rRNA catabolic process Source: GO_Central
rRNA processing Source: UniProtKB
U1 snRNA 3'-end processing Source: GO_Central
U4 snRNA 3'-end processing Source: GO_Central
U5 snRNA 3'-end processing Source: GO_Central
Cellular Location
Nucleolus; Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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