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Rabbit Anti-EYA2 Recombinant Antibody (BA0223) (CBMAB-0280CQ)

This product is a rabbit antibody that recognizes EYA2. The antibody BA0223 can be used for immunoassay techniques such as: WB, IP.
See all EYA2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
BA0223
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Synthetic peptide from residues near the N terminal region of Human EYA2
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
eyes absent homolog 2 (Drosophila)
Introduction
This gene encodes a member of the eyes absent (EYA) family of proteins. The gene is a human homolog of the Drosophila 'eyes absent' (eya), and was therefore called EYA1 (601653). A highly conserved 271-amino acid C-terminal region was also found in the products of 2 other human genes that were subsequently called EYA2 and EYA3 (601655), demonstrating the existence of a novel gene family. Some of these other members of the EYA gene family may underlie developmental defects, because Abdelhak et al. (1997) demonstrated that all 3 of these genes are expressed in the ninth week of human development. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.
Entrez Gene ID
2139
UniProt ID
O00167
Alternative Names
EYA Transcriptional Coactivator And Phosphatase 2; EC 3.1.3.48; EAB1; Eyes Absent (Drosophila) Homolog 2; Eyes Absent Homolog 2 (Drosophila)
Research Area
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380).

Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884).

Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905).
Biological Process
Anatomical structure development Source: GO_Central
Cell differentiation Source: GO_Central
DNA repair Source: UniProtKB-KW
Extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Histone dephosphorylation Source: UniProtKB
Mesodermal cell fate specification Source: ProtInc
Mitochondrial outer membrane permeabilization Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Positive regulation of DNA repair Source: GO_Central
Striated muscle tissue development Source: Ensembl
Cellular Location
Nucleus; Cytoplasm. Retained in the cytoplasm via interaction with GNAZ and GNAI2 (PubMed:10906137). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus (PubMed:10906137, PubMed:12500905).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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