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Rabbit Anti-FASTKD2 Recombinant Antibody (EG1175) (CBMAB-EN1413-LY)

The product is antibody recognizes FAKD2. The antibody EG1175 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:1000.
See all FASTKD2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1175
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human FAKD2.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
FAST Kinase Domains 2
Introduction
This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008]
Entrez Gene ID
22868
UniProt ID
Q9NYY8
Alternative Names
FAST Kinase Domains 2; KIAA0971; FAST Kinase Domain-Containing Protein 2, Mitochondrial;
Research Area
Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715).

As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664, PubMed:25683715, PubMed:26370583).

May play a role in mitochondrial apoptosis.
Biological Process
Apoptotic process Source: UniProtKB
Mitochondrial large ribosomal subunit assembly Source: UniProtKB
Mitochondrial translation Source: UniProtKB
Positive regulation of mitochondrial translation Source: UniProtKB
Regulation of mitochondrial mRNA stability Source: InterPro
RNA processing Source: UniProtKB
Cellular Location
Mitochondrion nucleoid; Mitochondrion matrix. Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids.
Involvement in disease
Combined oxidative phosphorylation deficiency 44 (COXPD44):
An autosomal recessive mitochondrial disorder characterized by onset in infancy or early childhood of global developmental delay, hypotonia, and abnormal movements. Combined oxidative phosphorylation deficiency is present in skeletal muscle. Most patients have seizures associated with status epilepticus. Additional variable features include optic atrophy, hypertrophic cardiomyopathy, stroke-like episodes, and increased lactate levels in serum and cerebrospinal fluid.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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