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Mouse Anti-FAM3A Recombinant Antibody (CBXF-2563) (CBMAB-F3012-CQ)

This product is a mouse antibody that recognizes FAM3A. The antibody CBXF-2563 can be used for immunoassay techniques such as: WB.
See all FAM3A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2563
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
NS0-derived recombinant human FAM3A, Phe34-Ser230, Accession # P98173
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Family With Sequence Similarity 3 Member A
Introduction
This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
60343
UniProt ID
P98173
Alternative Names
Family With Sequence Similarity 3 Member A; Cytokine-Like Protein 2-19; 2.19; Family With Sequence Similarity 3, Member A; Protein FAM3A; DXS560S; XAP-7; 2-19; DLD;
Research Area
May act as a defensin against invading fungal microorganisms.
Biological Process
Antifungal humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Negative regulation of antifungal innate immune response Source: UniProtKB
Negative regulation of gluconeogenesis Source: InterPro
Regulation of lipid biosynthetic process Source: InterPro
Cellular Location
Secreted

Abdi Ardekani, M., Banaei Far, A. A., Arshadi, S., & Abednatanzi, H. (2022). Effect of High Intensity Interval Training and Thyme Honey on Hepatic miR-423-5P, FAM3A, Akt2 Pathway of Type ll Diabetic rats. medical journal of mashhad university of medical sciences, 65(1).

Liu, X., Hou, S., Xiang, R., Hu, C., Chen, Z., Li, N., ... & Yang, J. (2022). Imipramine activates FAM3A-FOXA2-CPT2 pathway to ameliorate hepatic steatosis. Metabolism, 136, 155292.

Yan, H., Chen, Z., Zhang, H., Yang, W., Liu, X., Meng, Y., ... & Yang, J. (2022). Intracellular ATP signaling contributes to FAM3A-induced PDX1 upregulation in pancreatic Beta cells. Experimental and Clinical Endocrinology & Diabetes, 130(08), 498-508.

Song, Q., Gao, Q., Chen, T., Wen, T., Wu, P., Luo, X., & Chen, Q. Y. (2021). FAM3A Ameliorates Brain Impairment Induced by Hypoxia–Ischemia in Neonatal Rat. Cellular and Molecular Neurobiology, 1-14.

Xiang, R., Chen, J., Li, S., Yan, H., Meng, Y., Cai, J., ... & Yang, J. (2020). VSMC-specific deletion of FAM3A attenuated Ang II-promoted hypertension and cardiovascular hypertrophy. Circulation Research, 126(12), 1746-1759.

Liu, J., An, P., Xue, Y., Che, D., Liu, X., Zheng, J., ... & Yu, B. (2019). Mechanism of Snhg8/miR-384/Hoxa13/FAM3A axis regulating neuronal apoptosis in ischemic mice model. Cell Death & Disease, 10(6), 1-13.

Sala, D., Cunningham, T. J., Stec, M. J., Etxaniz, U., Nicoletti, C., Dall’Agnese, A., ... & Sacco, A. (2019). The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. Nature communications, 10(1), 1-16.

Yan, S., Jiang, C., Li, H., Li, D., & Dong, W. (2019). FAM3A protects chondrocytes against interleukin-1β-induced apoptosis through regulating PI3K/Akt/mTOR pathway. Biochemical and biophysical research communications, 516(1), 209-214.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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