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Rat Anti-FAM3C Recombinant Antibody (CBXF-2565) (CBMAB-F3014-CQ)

This product is a rat antibody that recognizes FAM3C. The antibody CBXF-2565 can be used for immunoassay techniques such as: WB.
See all FAM3C antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXF-2565
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
NS0-derived recombinant mouse FAM3C, Gln25-Asp227, Accession # Q91VU0
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Family With Sequence Similarity 3 Member C
Introduction
This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells.
Entrez Gene ID
27999
UniProt ID
Q91VU0
Alternative Names
Family With Sequence Similarity 3 Member C; Interleukin-Like EMT Inducer; Interleukin-Like Epithelial-Mesenchymal Transition Inducer; Predicted Osteoblast Protein; ILEI; Family With Sequence Similarity 3, Member C; Protein FAM3C; GS3786;
Research Area
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
Biological Process
Negative regulation of gluconeogenesis Source: InterPro
Cellular Location
Secreted; Cytoplasmic vesicle. Cytoplasmic in some cancer cells.

Watanabe, N., Nakano, M., Mitsuishi, Y., Hara, N., Mano, T., Iwata, A., ... & Nishimura, M. (2022). Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain. Human molecular genetics, 31(1), 122-132.

Nakano, M., Imamura, R., Sugi, T., & Nishimura, M. (2022). Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70. 4 loss-of-function mutants. PNAS Nexus.

Zhu, Y., Pu, Z., Wang, G., Li, Y., Wang, Y., Li, N., & Peng, F. (2021). FAM3C: an emerging biomarker and potential therapeutic target for cancer. Biomarkers in Medicine, 15(5), 373-384.

Schmidt, U., Heller, G., Timelthaler, G., Heffeter, P., Somodi, Z., Schweifer, N., ... & Csiszar, A. (2021). The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness. Journal of Experimental & Clinical Cancer Research, 40(1), 1-21.

Nakano, M., Mitsuishi, Y., Liu, L., Watanabe, N., Hibino, E., Hata, S., ... & Nishimura, M. (2021). Extracellular release of ILEI/FAM3C and amyloid-β is associated with the activation of distinct synapse subpopulations. Journal of Alzheimer's Disease, 80(1), 159-174.

Song, Q., Song, J., Li, C., Wang, Y., Qi, L., & Wang, H. (2021). Genetic variants in the FAM3C gene are associated with lipid traits in Chinese children. Pediatric Research, 89(3), 673-678.

Yang, W., Feng, B., Meng, Y., Wang, J., Geng, B., Cui, Q., ... & Yang, J. (2019). FAM3C‐YY1 axis is essential for TGFβ‐promoted proliferation and migration of human breast cancer MDA‐MB‐231 cells via the activation of HSF1. Journal of cellular and molecular medicine, 23(5), 3464-3475.

Wu, C. C., Xiao, Y., Li, H., Mao, L., Deng, W. W., Yu, G. T., ... & Sun, Z. J. (2019). Overexpression of FAM3C is associated with poor prognosis in oral squamous cell carcinoma. Pathology-Research and Practice, 215(4), 772-778.

Shi, M., Duan, G., Nie, S., Shen, S., & Zou, X. (2018). Elevated FAM3C promotes cell epithelial–mesenchymal transition and cell migration in gastric cancer. OncoTargets and therapy, 11, 8491.

Yin, S., Chen, F., Ye, P., & Yang, G. (2018). Overexpression of FAM3C protein as a novel biomarker for epithelial-mesenchymal transition and poor outcome in gastric cancer. International Journal of Clinical and Experimental Pathology, 11(8), 4247.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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