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Rabbit Anti-FAM83H Recombinant Antibody (CBXF-1103) (CBMAB-F0795-CQ)

This product is a rabbit antibody that recognizes FAM83H. The antibody CBXF-1103 can be used for immunoassay techniques such as: WB.
See all FAM83H antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXF-1103
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Family With Sequence Similarity 83 Member H
Introduction
The protein encoded by this gene plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a cause of amelogenesis imperfecta type 3 (AI3).
Entrez Gene ID
286077
UniProt ID
Q6ZRV2
Alternative Names
Family With Sequence Similarity 83 Member H; Family With Sequence Similarity 83, Member H; FAM83H Variant 1; FAM83H Variant 2; Protein FAM83H; AI3A; AI3;
Research Area
May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228).

May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688).
Biological Process
Biomineral tissue development Source: UniProtKB-KW
Intermediate filament cytoskeleton organization Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Protein localization to cytoskeleton Source: UniProtKB
Signal transduction Source: GO_Central
Cellular Location
Cytoskeleton. Colocalizes with keratin filaments.
Involvement in disease
Amelogenesis imperfecta 3A (AI3A):
An autosomal dominant hypomineralized form of amelogenesis imperfecta, a defect of enamel formation. AI3A is characterized by enamel of normal thickness but soft and with cheesy consistency. Enamel is lost from tooth soon after eruption.

Kuga, T., Inoue, N., Sometani, K., Murataka, S., Saraya, M., Sugita, R., ... & Yamagishi, N. (2022). The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton. Scientific reports, 12(1), 1-12.

El‐Ashmawy, N. E., Al‐Ashmawy, G. M., & Hamouda, S. M. (2021). Long non‐coding RNA FAM83H‐AS1 as an emerging marker for diagnosis, prognosis and therapeutic targeting of cancer. Cell Biochemistry and Function, 39(3), 350-356.

Wang, S. K., Zhang, H., Hu, C. Y., Liu, J. F., Chadha, S., Kim, J. W., ... & Hu, J. C. (2021). FAM83H and autosomal dominant hypocalcified amelogenesis imperfecta. Journal of dental research, 100(3), 293-301.

Wang, S., Han, C., Liu, T., Ma, Z., Qiu, M., Wang, J., ... & Yin, R. (2021). FAM83H‐AS1 is a noncoding oncogenic driver and therapeutic target of lung adenocarcinoma. Clinical and translational medicine, 11(2), e316.

Yang, Q., Wang, J., Zhong, P., Mou, T., Hua, H., Liu, P., & Xie, F. (2020). The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis. Cancer cell international, 20(1), 1-11.

Han, C., Fu, Y., Zeng, N., Yin, J., & Li, Q. (2020). LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis. Aging (Albany NY), 12(4), 3594.

El-Ashmawy, N. E., Hussien, F. Z., El-Feky, O. A., Hamouda, S. M., & Al-Ashmawy, G. M. (2020). Serum LncRNA-ATB and FAM83H-AS1 as diagnostic/prognostic non-invasive biomarkers for breast cancer. Life Sciences, 259, 118193.

Shan, H., Yang, Y., Zhu, X., Han, X., Zhang, P., & Zhang, X. (2019). FAM83H‐AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer. Journal of cellular biochemistry, 120(3), 4687-4693.

Dou, Q., Xu, Y., Zhu, Y., Hu, Y., Yan, Y., & Yan, H. (2019). LncRNA FAM83H-AS1 contributes to the radioresistance, proliferation, and metastasis in ovarian cancer through stabilizing HuR protein. European Journal of Pharmacology, 852, 134-141.

Kim, K. M., Hussein, U. K., Bae, J. S., Park, S. H., Kwon, K. S., Ha, S. H., ... & Jang, K. Y. (2019). The expression patterns of FAM83H and PANX2 are associated with shorter survival of clear cell renal cell carcinoma patients. Frontiers in oncology, 9, 14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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