Mouse Anti-FARSB Recombinant Antibody (2F11) (CBMAB-A2837-LY)

The product is antibody recognizes FARSLB. The antibody 2F11 immunoassay techniques such as: WB, ELISA.
See all FARSB antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2F11

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Immunogen

FARSLB (NP_005678, 234 a.a. ~ 341 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Phenylalanyl-TRNA Synthetase Beta Subunit

Introduction

This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. [provided by RefSeq]

Entrez Gene ID

10056

UniProt ID

Q9NSD9

Alternative Names

FARSLB; FRSB; HSPC173; PheHB; PheRS

Biological Process

Phenylalanyl-tRNA aminoacylation Source: UniProtKB
Protein heterotetramerization Source: UniProtKB
Translation Source: ProtInc

Cellular Location

Cytoplasm

Involvement in disease

Rajab interstitial lung disease with brain calcifications (RILDBC):
An autosomal recessive, lethal neurodevelopmental disorder characterized by multiple clinical manifestations including intrauterine growth restriction, failure to thrive, developmental delay, hypotonia, interstitial lung disease, and liver dysfunction. Brain imaging shows abnormal periventricular white matter, basal ganglia echogenicity, cerebral volume loss, incomplete closure of the Sylvian fissures, and normal myelination.

References

Karimzadeh, P., Rezakhani, S., Miryounesi, M., & Alijanpour, S. (2022). Neurodegenerative disorder and diffuse brain calcifications due to FARSB mutation in two siblings. Clinical Case Reports, 10(8), e6195.

Zhen, J., Pan, J., Zhou, X., Yu, Z., Jiang, Y., Gong, Y., ... & Huang, D. (2022). FARSB Serves as a Novel Hypomethylated and Immune Cell Infiltration Related Prognostic Biomarker in Hepatocellular carcinoma.

Krenke, K., Szczałuba, K., Bielecka, T., Rydzanicz, M., Lange, J., Koppolu, A., & Płoski, R. (2019). FARSA mutations mimic phenylalanyl‐tRNA synthetase deficiency caused by FARSB defects. Clinical Genetics, 96(5), 468-472.

Zadjali, F., Al‐Yahyaee, A., Al‐Nabhani, M., Al‐Mubaihsi, S., Gujjar, A., Raniga, S., & Al‐Maawali, A. (2018). Homozygosity for FARSB mutation leads to Phe‐tRNA synthetase‐related disease of growth restriction, brain calcification, and interstitial lung disease. Human Mutation, 39(10), 1355-1359.

Antonellis, A., Oprescu, S. N., Griffin, L. B., Heider, A., Amalfitano, A., & Innis, J. W. (2018). Compound heterozygosity for loss‐of‐function FARSB variants in a patient with classic features of recessive aminoacyl‐tRNA synthetase‐related disease. Human mutation, 39(6), 834-840.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-FARSB Recombinant Antibody (2F11)

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Mouse Anti-FARSB Recombinant Antibody (2F11)

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Mouse Anti-FARSB Recombinant Antibody (CBXF-0304)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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