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Mouse Anti-FBXO3 Recombinant Antibody (CBXF-1729) (CBMAB-F3264-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXF-1729
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F-box protein 3
Introduction
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end.
Entrez Gene ID
Human26273
Mouse57443
Rat690634
UniProt ID
HumanQ9UK99
MouseQ9DC63
RatD4ABP9
Alternative Names
F-Box Protein 3; F-Box Only Protein 3; FBX3; F-Box Protein FBX3; FBA;
Research Area
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
Biological Process
Proteolysis Source: ProtInc
Cellular Location
Nucleus. Colocalizes with PML at the peripheries of nuclear bodies.
More Infomation

Wang, Q., Huang, P. Y., Wu, J. G., Zhang, T. Q., Li, L. F., Huang, L. D., ... & He, J. (2022). miR‐219a‐5p inhibits the pyroptosis in knee osteoarthritis by inactivating the NLRP3 signaling via targeting FBXO3. Environmental Toxicology, 37(11), 2673-2682.

Gao, Y., Xiao, X., Luo, J., Wang, J., Peng, Q., Zhao, J., ... & Zhao, Y. (2022). E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury. International Journal of Molecular Sciences, 23(21), 13648.

Niu, M., He, Y., Xu, J., Ding, L., He, T., Yi, Y., ... & Xiao, Z. X. J. (2021). Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis. PLoS biology, 19(2), e3001113.

Hsieh, M. C., Ho, Y. C., Lai, C. Y., Wang, H. H., Yang, P. S., Cheng, J. K., ... & Peng, H. Y. (2021). Blocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief. Neurotherapeutics, 18(2), 1295-1315.

Li, J., & Ma, L. (2020). MiR-142-3p attenuates oxygen glucose deprivation/reoxygenation-induced injury by targeting FBXO3 in human neuroblastoma SH-SY5Y cells. World Neurosurgery, 136, e149-e157.

Li, Z., Fan, S., Wang, J., Chen, X., Liao, Q., Liu, X., ... & Xiao, W. (2020). Zebrafish F-box protein fbxo3 negatively regulates antiviral response through promoting K27-linked polyubiquitination of the transcription factors irf3 and irf7. The Journal of Immunology, 205(7), 1897-1908.

Watanabe, Y., Nakagawa, T., Akiyama, T., Nakagawa, M., Suzuki, N., Warita, H., ... & Nakayama, K. (2020). An amyotrophic lateral sclerosis-associated mutant of C21ORF2 is stabilized by NEK1-mediated hyperphosphorylation and the inability to bind FBXO3. Iscience, 23(9), 101491.

Hung, K. Y., Liao, W. I., Pao, H. P., Wu, S. Y., Huang, K. L., & Chu, S. J. (2019). Targeting F-box protein Fbxo3 attenuates lung injury induced by ischemia-reperfusion in rats. Frontiers in Pharmacology, 10, 583.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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