Mouse Anti-FGGY (AA 1-100) Recombinant Antibody (CBXF-0640) (CBMAB-F0414-CQ)

This product is a mouse antibody that recognizes FGGY (AA 1-100). The antibody CBXF-0640 can be used for immunoassay techniques such as: ELISA, WB.
See all FGGY antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXF-0640

Antibody Isotype

IgG2b, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-100

Target

Full Name

FGGY Carbohydrate Kinase Domain Containing

Introduction

This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

55277

UniProt ID

Q96C11

Alternative Names

FGGY Carbohydrate Kinase Domain Containing; FGGY Carbohydrate Kinase Domain-Containing Protein; D-Ribulokinase; EC 2.7.1.-; EC 2.7.1;

Function

Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency.

Biological Process

Carbohydrate phosphorylation Source: UniProtKB
Neuron cellular homeostasis Source: UniProtKB
Pentose metabolic process Source: SGD

Involvement in disease

Amyotrophic lateral sclerosis (ALS):
A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.

References

Smith, A. L., Gjoka, E., Izhar, M., Novo, K. J., Mason, B. C., De Las Casas, A., & Waddell, D. S. (2021). FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling. Gene, 800, 145836.

Smith, A., Izhar, M., Gjoka, E., Novo, K., & Waddell PhD, D. (2020). Fggy Carbohydrate Kinase Domain Containing is Induced During Skeletal Muscle Atrophy and Regulates MAP Kinase Signaling.

Izhar, M., Smith, A., & Waddell, D. (2019). FGGY Carbohydrate Kinase Domain Containing (Fggy) is Expressed and Alternatively Spliced in Skeletal Muscle. The FASEB Journal, 33(S1), 700-16.

Taylor, J. A., Shioda, K., Mitsunaga, S., Yawata, S., Angle, B. M., Nagel, S. C., ... & Shioda, T. (2018). Prenatal exposure to bisphenol A disrupts naturally occurring bimodal DNA methylation at proximal promoter of fggy, an obesity-relevant gene encoding a carbohydrate kinase, in gonadal white adipose tissues of CD-1 mice. Endocrinology, 159(2), 779-794.

Novo, K., & Waddell, D. (2018). Identification and Characterization of FGGY Carbohydrate Kinase Domain Containing (Fggy) in Skeletal Muscle. The FASEB Journal, 32, 856-21.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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