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Mouse Anti-FIGLA Recombinant Antibody (CBXF-0683) (CBMAB-F3183-CQ)

This product is a mouse antibody that recognizes FIGLA. The antibody CBXF-0683 can be used for immunoassay techniques such as: S-ELISA, WB, ELISA.
See all FIGLA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0683
Antibody Isotype
IgG2a, κ
Application
S-ELISA, WB, ELISA

Basic Information

Immunogen
FIGLA (NP_001004311.1, 110 a.a.-219 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
folliculogenesis specific basic helix-loop-helix
Introduction
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6.
Entrez Gene ID
344018
UniProt ID
Q6QHK4
Alternative Names
Folliculogenesis Specific BHLH Transcription Factor; Folliculogenesis-Specific Basic Helix-Loop-Helix Protein; Class C Basic Helix-Loop-Helix Protein 8; Factor In The Germline Alpha; Transcription Factor FIGa; FIGALPHA; BHLHC8; Folliculogenesis Specific Basic Helix-Loop-Helix; POF6;
Function
Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
Biological Process
Developmental process Source: GO_Central
Oocyte development Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Premature ovarian failure 6 (POF6):
An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

Curzon, A. Y., Shirak, A., Benet-Perlberg, A., Naor, A., Low-Tanne, S. I., Sharkawi, H., ... & Seroussi, E. (2022). Absence of Figla-like Gene Is Concordant with Femaleness in Cichlids Harboring the LG1 Sex-Determination System. International Journal of Molecular Sciences, 23(14), 7636.

Qu, J., Li, R., Liu, Y., Sun, M., Yan, W., Liu, J., ... & Zhang, Q. (2022). Molecular Characterization, Expression Pattern and Transcriptional Regulation of Figla During Gonad Development in Japanese Founder (Paralichthys olivaceus). Journal of Ocean University of China, 21(4), 1037-1050.

Okunomiya, A., Horie, A., Tani, H., Sato, Y., Takamatsu, S., Brown, J. B., ... & Mandai, M. (2021). Figla promotes secondary follicle growth in mature mice. Scientific reports, 11(1), 1-10.

Cheng, J., Qin, W. J., Balsai, N., Shang, X. J., Zhang, M. T., & Chen, H. Q. (2020). Transcriptional activity of FIGLA, NEUROG2, and EGR1 transcription factors associated with polymorphisms in the proximal regulatory region of GPR54 gene in cattle. Animal reproduction science, 218, 106506.

Wang, Z., Liu, C. Y., Zhao, Y., & Dean, J. (2020). FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation. Nucleic acids research, 48(7), 3525-3541.

Liang, S., Wang, W., Wang, L., Wu, Z., Zou, Y., Tan, X., ... & You, F. (2020). Figla gene roles in the proliferation of oocytes in the olive flounder Paralichthys olivaceus. Aquaculture, 528, 735493.

Yuan, P., He, Z., Sun, S., Li, Y., Wang, W., Liang, X., ... & Yang, D. (2019). Bi‐allelic recessive loss‐of‐function mutations in FIGLA cause premature ovarian insufficiency with short stature. Clinical Genetics, 95(3), 409-414.

Chen, B., Li, L., Wang, J., Li, T., Pan, H., Liu, B., ... & Wang, B. (2018). Consanguineous familial study revealed biallelic FIGLA mutation associated with premature ovarian insufficiency. Journal of ovarian research, 11(1), 1-6.

Qin, M., Zhang, Z., Song, W., Wong, Q. W. L., Chen, W., Shirgaonkar, N., & Ge, W. (2018). Roles of Figla/figla in juvenile ovary development and follicle formation during zebrafish gonadogenesis. Endocrinology, 159(11), 3699-3722.

Zhou, Q., Zhu, Y., Chen, Z., Wang, L., Li, W., Lu, S., & Chen, S. (2018). Identification and expression analysis of figla gene in the turbot, Scophthalmus maximus. Aquaculture Research, 49(11), 3483-3490.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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