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Rabbit Anti-FLII Recombinant Antibody (CBXF-1189) (CBMAB-F0916-CQ)

This product is a rabbit antibody that recognizes FLII. The antibody CBXF-1189 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all FLII antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXF-1189
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
flagellum-specific ATP synthase
Introduction
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
Entrez Gene ID
2314
UniProt ID
Q13045
Alternative Names
FLII, Actin Remodeling Protein; Flightless I Actin Binding Protein; FLIL; Flightless I (Drosophila) Homolog; Flightless I Homolog (Drosophila); Protein Flightless-1 Homolog; Flightless I Homolog; Fli1; FLI;
Function
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity).

May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
Biological Process
Actin filament severing Source: GO_Central
Actin polymerization or depolymerization Source: GO_Central
Barbed-end actin filament capping Source: GO_Central
Myofibril assembly Source: GO_Central
Cellular Location
Nucleus; Cytoskeleton; Centrosome; Focal adhesion. Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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