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Mouse Anti-GRWD1 Recombinant Antibody (CBLG1-3211) (CBMAB-G5099-LY)

This product is antibody recognizes GRWD1. The antibody CBLG1-3211 immunoassay techniques such as: WB.
See all GRWD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBLG1-3211
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutamate-rich WD repeat containing 1
Introduction
This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
Entrez Gene ID
Human83743
Mouse101612
UniProt ID
HumanQ9BQ67
MouseQ810D6
Function
Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).
Biological Process
DNA replication Source: UniProtKB
Nucleosome assembly Source: UniProtKB
Nucleosome disassembly Source: UniProtKB
Cellular Location
Nucleolus; Nucleus; Chromosome. Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (PubMed:25990725).

Ichikawa, M. K., & Saitoh, M. (2022). Direct and indirect roles of GRWD1 in the inactivation of p53 in cancer. The Journal of Biochemistry, 171(6), 601-603.

Yao, L., & Tian, F. (2022). GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway. Experimental and Therapeutic Medicine, 24(1), 1-13.

Zhou, X., Shang, J., Liu, X., Zhuang, J. F., Yang, Y. F., Zhang, Y. Y., & Guan, G. X. (2021). Clinical significance and oncogenic activity of GRWD1 overexpression in the development of colon carcinoma. OncoTargets and therapy, 14, 1565.

Wei, S., Lu, S., Liang, L., Wang, X., Li, W., Li, T., ... & Gao, S. J. (2021). GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus-Induced Cellular Transformation. Mbio, 12(6), e03431-21.

Deng, X., Li, S., Kong, F., Ruan, H., Xu, X., Zhang, X., ... & Guan, M. (2020). Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer. Theranostics, 10(1), 265.

Wang, Q., Ren, H., Xu, Y., Jiang, J., Wudu, M., Liu, Z., ... & Qiu, X. (2020). GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway. Experimental Cell Research, 387(2), 111806.

Fujiyama, H., Tsuji, T., Hironaka, K., Yoshida, K., Sugimoto, N., & Fujita, M. (2020). GRWD1 directly interacts with p53 and negatively regulates p53 transcriptional activity. The journal of biochemistry, 167(1), 15-24.

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., ... & Fujita, M. (2018). GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system. Journal of cell science, 131(15), jcs213009.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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