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Mouse Anti-HPV18 E6 Recombinant Antibody (A275) (CBMAB-AP3174LY)


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Summary

Host Animal
Mouse
Specificity
Virus
Clone
A275
Antibody Isotype
IgG
Application
ELISA, IP, WB

Basic Information

Immunogen
HPV18E6-beta-galactosidase fusion protein synthesized in E. coli
Specificity
Virus
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
HPV18 E6
Alternative Names
HPV-18 E6, HPV-18 E6 protein, HPV18 E6, HPV18E6
Function
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
Biological Process
Modulation by virus of host apoptotic process Source: UniProtKB-KW
Modulation by virus of host ubiquitin-protein ligase activity Source: UniProtKB-UniRule
Negative regulation of transcription, DNA-templated Source: CACAO
Suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-UniRule
Suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity Source: UniProtKB-UniRule
Transcription, DNA-templated Source: UniProtKB-UniRule
Cellular Location
Host cytoplasm; Host nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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