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Rabbit Anti-HRH3 Recombinant Antibody (EG1555) (CBMAB-EN1856-LY)

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Basic Information

Host Animal
Rabbit
Clone
EG1555
Application
WB: 1:500~1:1000 ELISA: 1:1000
Immunogen
The antibody was produced against synthesized peptide derived from internal of human HRH3.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
histamine receptor H3
Introduction
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.
Entrez Gene ID
Human11255
Mouse99296
Rat85268
UniProt ID
HumanQ9Y5N1
MouseP58406
RatQ9QYN8
Alternative Names
HH3R; GPCR97
Function
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
Cognition Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Negative regulation of glutamate secretion Source: GO_Central
Negative regulation of serotonin secretion Source: GO_Central
Neurotransmitter secretion Source: ProtInc
Regulation of norepinephrine secretion Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-39
Helical: 40-60
Cytoplasmic: 61-70
Helical: 71-91
Extracellular: 92-108
Helical: 109-129
Cytoplasmic: 130-156
Helical: 157-177
Extracellular: 178-196
Helical: 197-217
Cytoplasmic: 218-359
Helical: 360-380
Extracellular: 381-395
Helical: 396-416
Cytoplasmic: 417-445

Fan, L. S., Chen, Y. C., Liao, R. J., Zhao, Y. Y., Zhang, X. N., Chen, Z., ... & Hu, W. W. (2022). Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia. Acta Pharmacologica Sinica, 43(11), 2807-2816.

Zhao, Y. Y., Jia, J., Zhang, J. J., Xun, Y. P., Xie, S. J., Liang, J. F., ... & Zhang, S. R. (2021). Inhibition of histamine receptor H3 suppresses the growth and metastasis of human non-small cell lung cancer cells via inhibiting PI3K/Akt/mTOR and MEK/ERK signaling pathways and blocking EMT. Acta Pharmacologica Sinica, 42(8), 1288-1297.

Zhang, C., Yu, Y., Ma, L., & Fu, P. (2020). Histamine H3 receptor promotes cell survival via regulating PKA/CREB/CDKN1A signal pathway in hepatocellular carcinoma. OncoTargets and therapy, 3765-3776.

Panula, P. (2020). Histamine, histamine H3 receptor, and alcohol use disorder. British Journal of Pharmacology, 177(3), 634-641.

Reichmann, F., Rimmer, N., Tilley, C. A., Dalla Vecchia, E., Pinion, J., Al Oustah, A., ... & Norton, W. H. (2020). The zebrafish histamine H3 receptor modulates aggression, neural activity and forebrain functional connectivity. Acta physiologica, 230(4), e13543.

Pallardo-Fernández, I., Muñoz-Rodríguez, J. R., González-Martín, C., & Alguacil, L. F. (2020). Histamine H3 receptor gene variants associated with drug abuse in patients with cocaine use disorder. Journal of Psychopharmacology, 34(11), 1326-1330.

Yu, D., Zhao, J., Wang, Y., Hu, J., Zhao, Q., Li, J., & Zhu, J. (2019). Upregulated histamine receptor H3 promotes tumor growth and metastasis in hepatocellular carcinoma. Oncology Reports, 41(6), 3347-3354.

Liao, R., Chen, Y., Cheng, L., Fan, L., Chen, H., Wan, Y., ... & Hu, W. (2019). Histamine H1 receptors in neural stem cells are required for the promotion of neurogenesis conferred by H3 receptor antagonism following traumatic brain injury. Stem cell reports, 12(3), 532-544.

Tiwari, A. K., Zhang, D., Pouget, J. G., Zai, C. C., Chowdhury, N. I., Brandl, E. J., ... & Müller, D. J. (2018). Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain. The World Journal of Biological Psychiatry, 19(sup3), S97-S105.

Puttonen, H. A. J., Sundvik, M., Semenova, S., Shirai, Y., Chen, Y. C., & Panula, P. (2018). Knockout of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish. Acta Physiologica, 222(3), e12981.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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