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Mouse Anti-IGBP1 Recombinant Antibody (2B8) (CBMAB-I0313-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B8
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Immunoglobulin Binding Protein 1
Introduction
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.
Entrez Gene ID
3476
UniProt ID
P78318
Alternative Names
Immunoglobulin Binding Protein 1
Function
Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.
Biological Process
B cell activation Source: UniProtKB-KW
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of stress-activated MAPK cascade Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of dephosphorylation Source: GO_Central
Regulation of microtubule-based movement Source: UniProtKB
Response to interleukin-1 Source: UniProtKB
Response to tumor necrosis factor Source: UniProtKB
Signal transduction Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Intellectual developmental disorder, X-linked, syndromic 28 (MRXS28):
A mental retardation syndrome characterized by agenesis of the corpus callosum, coloboma of the iris and optic nerve, severe retrognathia, and intellectual deficit. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Phosphorylated.By similarity
Monoubiquitination by MID1 triggers calpain-mediated cleavage and switches IGBP1 activity from protective to destructive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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