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Recombinant Mouse Anti-Influenza A Hemagglutinin H5(Avian H5N1) Antibody (CB513) (CBMAB-MD827-LY)

The product is antibody recognizes avian influenza. The antibody CB513 immunoassay techniques such as: DB, ELISA, HIA.
See all Influenza A Hemagglutinin H5(Avian H5N1) antibodies

Summary

Host Animal
Mouse
Specificity
avian influenza
Clone
CB513
Antibody Isotype
IgG2a
Application
DB, ELISA, HIA

Basic Information

Immunogen
Purified Avian Influenza Virus Type A (H5N1)
Specificity
avian influenza
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.05% ProClin 300
Purity
> 95% Purity determined by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Influenza A Hemagglutinin H5(Avian H5N1)
Function
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Biological Process
Clathrin-dependent endocytosis of virus by host cellIEA:UniProtKB-UniRule
Fusion of virus membrane with host endosome membraneIEA:UniProtKB-UniRule
Fusion of virus membrane with host plasma membraneIEA:InterPro
Viral budding from plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Virion attachment to host cellIEA:UniProtKB-KW
Cellular Location
Virion membrane; Host apical cell membrane. Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Topology
Extracellular: 18-528
Helical: 529-549
Cytoplasmic: 550-565
PTM
Palmitoylated.
In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by Clara cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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