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Mouse Anti-KLRK1 Recombinant Antibody (CBT3932) (V2LY-0625-LY1423)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3932
Antibody Isotype
IgG2a
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human CD314 (AA: extra 73-216) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Lectin Like Receptor K1
Entrez Gene ID
22914
UniProt ID
P26718
Function
Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cell differentiationIEA:UniProtKB-KW
Cellular response to lipopolysaccharideIEA:Ensembl
Defense response to Gram-positive bacteriumIEA:Ensembl
Natural killer cell activationManual Assertion Based On ExperimentTAS:BHF-UCL
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of GTPase activityManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of natural killer cell chemotaxisManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of interferon-gamma productionIEA:Ensembl
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of nitric oxide biosynthetic processIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Stimulatory C-type lectin receptor signaling pathwayIEA:Ensembl
T cell costimulationManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular Location
Cell membrane
Colocalized with HCST on the cell surface.
Topology
Cytoplasmic: 1-51
Helical: 52-72
Extracellular: 73-216
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For research use only. Not intended for any clinical use.

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