Mouse Anti-KREMEN2 Recombinant Antibody (276709) (CBMAB-K1533-LY)

Name: Mouse Anti-KREMEN2 Recombinant Antibody (276709)
SKU: CBMAB-K1533-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

276709

Antibody Isotype

IgG2b

Application

Basic Information

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Kremen-2, Gln19-Ala364

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Kringle Containing Transmembrane Protein 2

Introduction

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Entrez Gene ID

79412

UniProt ID

Q8NCW0

Alternative Names

Kringle Containing Transmembrane Protein 2; Kringle-Containing Protein Marking The Eye And The Nose; Kringle Domain-Containing Transmembrane Protein 2; Dickkopf Receptor 2; KRM2; Kremen Protein 2;

Function

Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.

Biological Process

Limb developmentISS:UniProtKB
Negative regulation of ossificationISS:UniProtKB
Wnt signaling pathwayIEA:UniProtKB-KW

Cellular Location

Membrane

Topology

Extracellular: 26-364
Helical: 365-387
Cytoplasmic: 388-462

More Infomation

References

Sun, Y., Gao, Y., Dong, M., Li, J., Li, X., He, N., ... & Xu, C. (2023). Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR. Journal of Experimental & Clinical Cancer Research, 42(1), 140.

Long, J., Cong, F., Wei, Y., Liu, J., & Tang, W. (2023). Increased Kremen2 predicts worse prognosis in colon cancer. Pathology and Oncology Research, 29, 1611082.

Liu, J., Zhu, B., Chen, J., & Cao, Y. (2023). Comprehensive Analysis of KREMEN2 as an Immunotherapeutic and Prognostic Biomarker in Pan-Cancer. Anticancer Research, 43(10), 4491-4509.

Chen, B., Wang, S. Q., Huang, J., Xu, W., Lv, H., Nie, C., ... & Chen, X. B. (2021). Knockdown of Kremen2 inhibits tumor growth and migration in gastric cancer. Frontiers in Oncology, 10, 534095.

Amaral, T. F., Xiao, Y., Estrada-Cortes, E., & Hansen, P. (2020). 49 Expression and actions of the dickkopf-1 receptors KREMEN1 and KREMEN2 in the bovine pre-implantation embryo. Reproduction, Fertility and Development, 32(2), 149-150.

Chen, B., Wang, S., Huang, J., Li, J., Zhang, J., Xu, W., ... & Chen, X. (2020). Knockdown of KREMEN2 inhibits tumor proliferation and metastasis in gastric cancer.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rabbit Anti-KREMEN2 Recombinant Antibody (CBLY1-140)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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