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Mouse Anti-CERS3 Recombinant Antibody (6C12) (CBMAB-A4865-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
6C12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
LASS3 (57 a.a. ~ 134 a.a) partial recombinant protein.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ceramide Synthase 3
Entrez Gene ID
Human204219
Mouse545975
Rat499174
UniProt ID
HumanQ8IU89
MouseQ1A3B0
RatB1H294
Alternative Names
CerS3; MGC27091
Function
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952).
It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960).
Biological Process
Ceramide biosynthetic process Source: UniProtKB
Cornification Source: UniProtKB
Epidermis development Source: UniProtKB
Keratinocyte differentiation Source: UniProtKB
Sphingolipid biosynthetic process Source: Reactome
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Ichthyosis, congenital, autosomal recessive 9 (ARCI9): A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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