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Mouse Anti-MAPKBP1 Recombinant Antibody (CBFYM-1668) (CBMAB-M1835-FY)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYM-1668
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MITOGEN-ACTIVATED PROTEIN KINASE BINDING PROTEIN 1
Introduction
This gene encodes a scaffold protein that regulates the JNK and NOD2 signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.
Entrez Gene ID
Human23005
Mouse26390
Rat362197
UniProt ID
HumanO60336
MouseQ6NS57
RatD3ZSY0
Alternative Names
Mitogen-Activated Protein Kinase Binding Protein 1; JNK-Binding Protein 1; JNKBP-1; JNKBP1; Mitogen Activated Protein Kinase Binding Protein 1; Mitogen-Activated Protein Kinase-Binding Protein 1; KIAA0596; NPHP20
Function
Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971).
Involved in JNK signaling pathway (By similarity).
Biological Process
Negative regulation of defense response to bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, spindle pole
Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells.
Involvement in disease
Nephronophthisis 20 (NPHP20):
A form of nephronophthisis, an autosomal recessive chronic tubulo-interstitial nephritis that progresses to end-stage renal failure. Some patients have cystic kidneys of normal size and no extrarenal manifestations, whereas others have enlarged renal size and severe extrarenal defects, including hypertrophic obstructive cardiomyopathy, aortic stenosis, pulmonary stenosis, patent ductus arteriosus, situs inversus, and periportal liver fibrosis. NPHP20 patients do not show extrarenal manifestations or evidence of a ciliopathy, such as situs inversus or polydactyly.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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