Mouse Anti-MAPKBP1 Recombinant Antibody (CBFYM-1668) (CBMAB-M1835-FY)

Name: Mouse Anti-MAPKBP1 Recombinant Antibody (CBFYM-1668)
SKU: CBMAB-M1835-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-1668

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MITOGEN-ACTIVATED PROTEIN KINASE BINDING PROTEIN 1

Introduction

This gene encodes a scaffold protein that regulates the JNK and NOD2 signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.

Entrez Gene ID

Human	23005
Mouse	26390
Rat	362197

UniProt ID

Human	O60336
Mouse	Q6NS57
Rat	D3ZSY0

Alternative Names

Mitogen-Activated Protein Kinase Binding Protein 1; JNK-Binding Protein 1; JNKBP-1; JNKBP1; Mitogen Activated Protein Kinase Binding Protein 1; Mitogen-Activated Protein Kinase-Binding Protein 1; KIAA0596; NPHP20

Function

Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971).
Involved in JNK signaling pathway (By similarity).

Biological Process

Negative regulation of defense response to bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, spindle pole
Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells.

Involvement in disease

Nephronophthisis 20 (NPHP20):
A form of nephronophthisis, an autosomal recessive chronic tubulo-interstitial nephritis that progresses to end-stage renal failure. Some patients have cystic kidneys of normal size and no extrarenal manifestations, whereas others have enlarged renal size and severe extrarenal defects, including hypertrophic obstructive cardiomyopathy, aortic stenosis, pulmonary stenosis, patent ductus arteriosus, situs inversus, and periportal liver fibrosis. NPHP20 patients do not show extrarenal manifestations or evidence of a ciliopathy, such as situs inversus or polydactyly.

Al-Hamed, M. H., Alzaidan, H., Hussein, M., Albaik, L., Qari, A., Sayer, J. A., & Imtiaz, F. (2021). Novel pathogenic MAPKBP1 variant in a family with nephronophthisis. Clinical Kidney Journal, 14(2), 728-730.

Schönauer, R., Jin, W., Ertel, A., Nemitz-Kliemchen, M., Panitz, N., Hantmann, E., ... & Halbritter, J. (2020). Novel nephronophthisis-associated variants reveal functional importance of MAPKBP1 dimerization for centriolar recruitment. Kidney international, 98(4), 958-969.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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