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Mouse Anti-NAA15 Recombinant Antibody (CBWJN-0388) (CBMAB-N1009-WJ)

This product is a Mouse antibody that recognizes NAA15. The antibody CBWJN-0388 can be used for immunoassay techniques such as: WB, Dot.
See all NAA15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0388
Antibody Isotype
IgG1
Application
WB, Dot

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Introduction
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Entrez Gene ID
80155
UniProt ID
Q9BXJ9
Alternative Names
N(Alpha)-Acetyltransferase 15, NatA Auxiliary Subunit; NMDA Receptor-Regulated Protein 1; N-Terminal Acetyltransferase; Gastric Cancer Antigen Ga19; NMDA Receptor Regulated 1; Protein Tubedown-1; TBDN100; NARG1; Ga19;
Function
Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062).

The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142).

Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548).

In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306).
Biological Process
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
N-terminal peptidyl-methionine acetylation Source: GO_Central
N-terminal protein amino acid acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein stabilization Source: UniProtKB
Cellular Location
Nucleus
Cytoplasm
Note: Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
Involvement in disease
Intellectual developmental disorder, autosomal dominant 50, with behavioral abnormalities (MRD50):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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