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Mouse Anti-NAA20 Recombinant Antibody (CBWJN-0937) (CBMAB-N0093-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0937
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N(alpha)-acetyltransferase 20, NatB catalytic subunit
Introduction
NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]
Entrez Gene ID
51126
UniProt ID
P61599
Alternative Names
N(Alpha)-Acetyltransferase 20, NatB Catalytic Subunit; N-Acetyltransferase 5, ARD1 Subunit (Arrest-Defective 1, S. Cerevisiae, Homolog); N-Terminal Acetyltransferase B Complex Catalytic Subunit NAA20; N-Terminal Acetyltransferase B Complex Catalytic Subunit NAT5; N-Acetyltransferase 5 (ARD1 Homolog, S. Cerevisiae); N-Acetyltransferase 5 (GCN5-Related, Putative); Methionine N-Acetyltransferase; NatB Complex Subunit NAT5; NatB Catalytic Subunit; N-Acetyltransferase 5; NAT5;
Function
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
Biological Process
N-terminal peptidyl-methionine acetylation Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
More Infomation

Wasel, S. (2023). Investigating a novel CRISPR created mutation in the Naa20 gene of Drosophila melanogaster.Wasel, S. (2023). Investigating a novel CRISPR created mutation in the Naa20 gene of Drosophila melanogaster.

Qiao, L., Dong, C., Jia, W., & Ma, B. (2023). NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling. Cellular Signalling, 112, 110922.

D'Onofrio, G., Cuccurullo, C., Larsen, S. K., Severino, M., D'Amico, A., Brønstad, K., ... & Bilo, L. (2023). Novel biallelic variants expand the phenotype of NAA20‐related syndrome. Clinical Genetics.

Morrison, J., Altuwaijri, N. K., Brønstad, K., Aksnes, H., Alsaif, H. S., Evans, A., ... & Arnesen, T. (2021). Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly. Genetics in Medicine, 23(11), 2213-2218.

Layer, D., Kopp, J., Fontanillo, M., Köhn, M., Lapouge, K., & Sinning, I. (2021). Structural basis of Naa20 activity towards a canonical NatB substrate. Communications biology, 4(1), 2.

Jung, T. Y., Ryu, J. E., Jang, M. M., Lee, S. Y., Jin, G. R., Kim, C. W., ... & Kim, H. S. (2020). Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1–AMPK–mTOR axis. Experimental & Molecular Medicine, 52(11), 1831-1844.

Lasa, M., Neri, L., Carte, B., Gázquez, C., Aragón, T., & Aldabe, R. (2020). Maturation of NAA20 aminoterminal end is essential to assemble NatB N-terminal acetyltransferase complex. Journal of molecular biology, 432(22), 5889-5901.

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For research use only. Not intended for any clinical use.

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