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Rabbit Anti-NDUFA9 Recombinant Antibody (CBWJN-1256) (CBMAB-N1622-WJ)

This product is a Rabbit antibody that recognizes NDUFA9. The antibody CBWJN-1256 can be used for immunoassay techniques such as: WB, IP, IHC-P.
See all NDUFA9 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBWJN-1256
Antibody Isotype
IgG
Application
WB, IP, IHC-P

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
Introduction
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. [provided by RefSeq, May 2010]
Entrez Gene ID
Human4704
Mouse66108
Rat362440
UniProt ID
HumanQ16795
MouseQ9DC69
RatQ5BK63
Alternative Names
NADH:Ubiquinone Oxidoreductase Subunit A9; NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 9, 39kDa; Short Chain Dehydrogenase/Reductase Family 22E, Member 1; NADH-Ubiquinone Oxidoreductase 39 KDa Subunit; Complex I 39kDa Subunit; NDUFS2L; CI-39kD; NADH Dehydrogenase (Ubiquinone) Fe-S Protein 2-Like (NADH-Coenzyme Q Reductase);
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Required for proper complex I assembly (PubMed:28671271).

Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Biological Process
Aerobic respiration Source: ComplexPortal
Circadian rhythm Source: UniProtKB
Mitochondrial ATP synthesis coupled proton transport Source: ComplexPortal
Mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
Mitochondrial respiratory chain complex I assembly Source: UniProtKB
Sodium ion transport Source: UniProtKB
Ubiquinone-6 biosynthetic process Source: GO_Central
Cellular Location
Mitochondrion matrix
Involvement in disease
Mitochondrial complex I deficiency, nuclear type 26 (MC1DN26):
A form of mitochondrial complex I deficiency, the most common biochemical signature of mitochondrial disorders, a group of highly heterogeneous conditions characterized by defective oxidative phosphorylation, which collectively affects 1 in 5-10000 live births. Clinical disorders have variable severity, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. MC1DN26 transmission pattern is consistent with autosomal recessive inheritance.
PTM
Acetylated on lysine residues. BLOC1S1 is required for acetylation (PubMed:22309213). Acetylated by CLOCK in a circadian manner (PubMed:28985504).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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