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Mouse Anti-PAWR Recombinant Antibody (13B602) (CBMAB-P0849-YC)

Provided herein is a Mouse monoclonal antibody against Human Pro-Apoptotic WT1 Regulator. The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all PAWR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13B602
Antibody Isotype
IgG1
Application
ELISA, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
0.03% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PAWR
Introduction
PAWR is a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
Entrez Gene ID
5074
UniProt ID
Q96IZ0
Alternative Names
Pro-Apoptotic WT1 Regulator; PRKC, Apoptosis, WT1, Regulator; Prostate Apoptosis Response-4; PAR-4; PAR4; Prostate Apoptosis Response Protein PAR-4;
Function
Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Biological Process
Actin filament bundle assemblyISS:UniProtKB
Apoptotic processISS:UniProtKB
Apoptotic signaling pathwayIEA:Ensembl
Negative regulation of B cell proliferationIEA:Ensembl
Negative regulation of fibroblast proliferationIEA:Ensembl
Negative regulation of gene expressionIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Negative regulation of T cell receptor signaling pathwayIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of amyloid precursor protein biosynthetic processIEA:Ensembl
Positive regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular senescenceIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of hydrogen peroxide-mediated programmed cell deathIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity).
Nuclear localization includes nucleoplasm and PML nuclear bodies.
PTM
Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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