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Mouse Anti-PCDH19 Recombinant Antibody (2G10) (CBMAB-P0968-YC)

Provided herein is a Mouse monoclonal antibody against Human Protocadherin 19. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PCDH19 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G10
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PCDH19 (NP_065817, 241-340 aa) partial recombinant protein with GST tag. Immunogen sequence: RLVPRDVEET DKMNVVSCSS LTSSLNYFDY HQQTLPLGCR RSESTFLNVE NQNTRNTSAN HIYHHSFNSQ GPQQPDLIIN GAPLPETENY SFDSNYVNSR
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 241-340

Target

Full Name
protocadherin 19
Introduction
PCDH19 is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Mutations in this gene on human chromosome X are associated with sporadic infantile epileptic encephalopathy and to a female-restricted form of epilepsy (EFMR; also known as PCDH19RE).
Entrez Gene ID
57526
UniProt ID
Q8TAB3
Alternative Names
Protocadherin 19; Epilepsy, Female Restricted, With Mental Retardation (Juberg-Hellman Syndrome); Protocadherin-19; KIAA1313; EIEE9; EFMR;
Function
Potential calcium-dependent cell-adhesion protein.
Biological Process
Brain developmentIEA:InterPro
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Cellular Location
Cell membrane
Involvement in disease
Developmental and epileptic encephalopathy 9 (DEE9):
A condition characterized by seizure with onset in infancy or early childhood, cognitive impairment, and delayed development of variable severity in some patients. Additional features include autistic signs and psychosis. The disorder is sex-limited, with the phenotype being restricted to females.
Topology
Extracellular: 22-678
Helical: 679-699
Cytoplasmic: 700-1148
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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