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Mouse Anti-PDK3 Recombinant Antibody (431CT6.1) (CBMAB-P1322-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
431CT6.1
Antibody Isotype
IgG2b
Application
WB, ELISA

Basic Information

Immunogen
Purified His-tagged PDK3 protein (Fragment)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pyruvate Dehydrogenase Kinase 3
Introduction
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles.
Entrez Gene ID
5165
UniProt ID
Q15120
Alternative Names
Pyruvate Dehydrogenase Kinase 3; Pyruvate Dehydrogenase Kinase, Isoenzyme 3; Pyruvate Dehydrogenase Kinase, Isozyme 3; EC 2.7.11.2; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 3, Mitochondrial; Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 3, Mitochondrial;
Function
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.
Biological Process
Cellular response to fatty acidManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to glucose stimulusISS:UniProtKB
Glucose metabolic processIEA:UniProtKB-KW
Hypoxia-inducible factor-1alpha signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Peroxisome proliferator activated receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of acetyl-CoA biosynthetic process from pyruvateManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of glucose metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion matrix
Involvement in disease
Charcot-Marie-Tooth disease, X-linked dominant, 6 (CMTX6):
A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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