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Mouse Anti-PRSS2 Recombinant Antibody (CBYJT-1586) (CBMAB-T0629-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to PRSS2 (Serine Protease 2). The antibody can be used for immunoassay techniques, such as WB, IP.
See all PRSS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1586
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Trypsin 2/PRSS2, Ala16-Ser247, Accession # P07478
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 16-247

Target

Full Name
Serine Protease 2
Introduction
PRSS2 belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. PRSS2 is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. PRSS2 has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, PRSS2 is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix.
Entrez Gene ID
5645
UniProt ID
P07478
Alternative Names
TRY2; TRY8; TRYP2
Function
In the ileum, may be involved in defensin processing, including DEFA5.
Biological Process
Antimicrobial humoral responseTAS:Reactome
Collagen catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
DigestionIEA:UniProtKB-KW
Extracellular matrix disassemblyTAS:Reactome
Positive regulation of cell adhesionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of cell growthManual Assertion Based On ExperimentTAS:UniProtKB
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted, extracellular space
PTM
Sulfated on tyrosine.
Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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